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Pentosan Polysulfate
Catalog No. T12420Cas No. 37300-21-3
Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.
Pentosan Polysulfate
Catalog No. T12420Cas No. 37300-21-3
Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $295 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis. |
| In vitro | Pentosan polysulfate inhibits HIV-1 activity (ED50 of 0.19 μg/mL in MT-4 cells), HIV-1 antigen expression in HUT-78 cells (ED50 of 0.02 μg/mL), and achieves complete inhibition of HIV-1 antigen expression at 4.0 μg/mL[2]. |
| In vivo | Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation,and also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys[3]. |
| Cas No. | 37300-21-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble) |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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