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QC6352
Catalog No. T16700Cas No. 1851373-36-8
QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
QC6352
Catalog No. T16700Cas No. 1851373-36-8
QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks | |
| 1 mL x 10 mM (in DMSO) | $434 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM). |
| Targets&IC50 | KDM4C:35 nM |
| In vitro | QC6352 is an effective KDM4C inhibitor (IC50: 35±8 nM). QC6352 blocks the proliferation and self-renewal of BCSCs. In a concentration-dependent manner QC6352 dramatically decreases the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. The protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352 [1][2]. |
| In vivo | QC6352 significantly inhibits tumor growth and final tumor weight in both BCSC1 and BCSC2 xenografts. The treatment is well tolerated, with no impact on mice body weight. Administration of the KDM4 inhibitor QC6352 effectively blocks BCSC xenograft tumor growth [2]. |
| Molecular Weight | 387.47 |
| Formula | C24H25N3O2 |
| Cas No. | 1851373-36-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (64.52 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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