Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Procaine hydrochloride

🥰Excellent
Catalog No. T0802Cas No. 51-05-8
Alias Procaine HCl, Novocaine HCl

Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

Procaine hydrochloride

Procaine hydrochloride

🥰Excellent
Purity: 100.00%
Catalog No. T0802Alias Procaine HCl, Novocaine HClCas No. 51-05-8
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
Pack SizePriceAvailabilityQuantity
500 mg$31In Stock
1 g$40In Stock
Bulk & Custom
Add to Cart
Questions
View More
Select Batch
Purity:100.00%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
Targets&IC50
5-HT3:1.7 μM(Kd), nAChR:45.5 μM, NMDAR:0.296 mM, Na+ channel:60 μM
In vitro
In anesthetized cats, Procaine (15 mg/kg) enhanced the cellular activity in the ventral hippocampal formation of the amygdala, the ventromedial hypothalamus, the septal nucleus, and the neocortex of the temporal lobe. Procaine acts as a stimulant for marginal system cells. Furthermore, Procaine facilitates the conduction of evoked stimulatory activity from the amygdala to the ventromedial hypothalamus.
In vivo
Procaine exhibits the ability to bind to or antagonize nicotinic acetylcholine receptors and the 5-HT(serotonin) receptor-ion channel complex, as well as N-methyl-D-aspartate (NMDA) receptors. Its primary mechanism of action involves the inhibition of sodium ion influx by affecting the voltage-gated sodium channels on the neuronal cell membranes of peripheral nerves. This disruption of sodium ion flow prevents the generation of action potentials, thereby inhibiting signal transduction. Studies suggest that the receptor sites targeted by procaine are located on the cytoplasmic (internal) portion of the sodium channels.
AliasProcaine HCl, Novocaine HCl
Chemical Properties
Molecular Weight272.77
FormulaC13H20N2O2·HCl
Cas No.51-05-8
SmilesCl.CCN(CC)CCOC(=O)c1ccc(N)cc1
Relative Density.1.1761 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (201.64 mM)
H2O: 50 mg/mL (183.3 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.6661 mL18.3305 mL36.6609 mL183.3046 mL
5 mM0.7332 mL3.6661 mL7.3322 mL36.6609 mL
10 mM0.3666 mL1.8330 mL3.6661 mL18.3305 mL
20 mM0.1833 mL0.9165 mL1.8330 mL9.1652 mL
50 mM0.0733 mL0.3666 mL0.7332 mL3.6661 mL
100 mM0.0367 mL0.1833 mL0.3666 mL1.8330 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Procaine hydrochloride | purchase Procaine hydrochloride | Procaine hydrochloride cost | order Procaine hydrochloride | Procaine hydrochloride chemical structure | Procaine hydrochloride in vivo | Procaine hydrochloride in vitro | Procaine hydrochloride formula | Procaine hydrochloride molecular weight