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S1P1 Agonist III

Name: S1P1 Agonist III
Brand: TargetMol
SKU: T16833
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16833Cas No. 1324003-64-6

S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM).

S1P1 Agonist III

😃Good

Catalog No. T16833Cas No. 1324003-64-6

S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM).

Pack Size	Price	Availability	Quantity
100 mg	$897	6-8 weeks

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Product Introduction

Bioactivity

Description

S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM).

In vitro

S1P1 agonist When dosed orally at 1 and 3 mg/kg, S1P1 Agonist III achieved a statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when S1P1 Agonist III was dosed orally at 2 and 100 mg/kg. S1P1 Agonist III displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).

Chemical Properties

Molecular Weight	415.37
Formula	C₂₁H₁₆F₃N₃O₃
Cas No.	1324003-64-6
Relative Density.	1.354 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 62.5 mg/mL (150.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4075 mL	12.0375 mL	24.0749 mL	120.3746 mL
5 mM	0.4815 mL	2.4075 mL	4.8150 mL	24.0749 mL
10 mM	0.2407 mL	1.2037 mL	2.4075 mL	12.0375 mL
20 mM	0.1204 mL	0.6019 mL	1.2037 mL	6.0187 mL
50 mM	0.0481 mL	0.2407 mL	0.4815 mL	2.4075 mL
100 mM	0.0241 mL	0.1204 mL	0.2407 mL	1.2037 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

S1P1 Agonist IIIS-1P1 Agonist III