Powder: -20°C for 3 years | In solvent: -80°C for 2 years
S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 119.00 | |
10 mg | 6-8 weeks | $ 189.00 | |
25 mg | 6-8 weeks | $ 310.00 | |
50 mg | 6-8 weeks | $ 491.00 | |
100 mg | 6-8 weeks | $ 884.00 |
Description | S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth. |
Synonyms | S-49076 Hydrochloride |
Molecular Weight | 439.85 |
Formula | C22H18ClN3O5 |
CAS No. | 1265966-31-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: Soluble
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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S49076 HCl 1265966-31-1 Angiogenesis Tyrosine Kinase/Adaptors FGFR TAM Receptor c-Met/HGFR S-49076 Hydrochloride S-49076 HCl inhibitor inhibit