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S49076 HCl

Catalog No. T3512 CAS 1265966-31-1

Synonyms: S-49076 Hydrochloride

S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth.

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S49076 HCl, CAS 1265966-31-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	S-49076 Hydrochloride
Molecular Weight	474.96
Formula	C22H23ClN4O4S
CAS No.	1265966-31-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Burbridge MF, et al. S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab. Mol Cancer Ther. 2013 Sep;12(9):1749-62.

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DS-1205 ONO-7475 2-D08 NPS-1034 Pralatrexate S49076 HCl S49076 UNC 569 hydrochloride

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Keywords

S49076 HCl 1265966-31-1 蛋白酪氨酸激酶血管生成 TAM Receptor c-Met/HGFR FGFR S-49076 Hydrochloride S-49076 HCl Inhibitor inhibitor inhibit

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