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SHA 68

Catalog No. T12895 CAS 847553-89-3

SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).

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SHA 68, CAS 847553-89-3

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Purity: 98%

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Storage & Solubility Information

Description	SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
Targets&IC50	Ile107:23.8 nM , Asn107:22 nM
In vivo	SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing[1].SHA 68 (i.v.; 1 mg/kg) has a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.SHA 68 (i.p.; 2.5 mg/kg) has a T1/2 of 0.43 hours, a CL of 4.56 mL/min/kg[1].

Molecular Weight	445.49
Formula	C26H24FN3O3
CAS No.	847553-89-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (561.18 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Okamura N, et al. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun;325(3):893-901. 2. Ensho T, et al. Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation.Neuropeptides. 2017 Oct;65:21-27.

Related Products

Related compounds with same targets

[Leu31,Pro34]-Neuropeptide Y (porcine) M871 acetate M617 acetate [D-Trp34]-Neuropeptide Y Acetate Neuropeptide S (Mouse) acetate Galanin (1-16), mouse, porcine, rat Neuropeptide Y (29-64), amide, human acetate Peptide YY (PYY) (3-36), human

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Keywords

SHA 68 847553-89-3 G蛋白偶联受体神经科学 Neuropeptide Y Receptor SHA-68 NPSR Ile107 SHA68 neuropeptide receptor NPSR BBB Inhibitor Asn107 NPY receptor inhibit non-peptide neuralgia inhibitor

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