Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
Description | SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively). |
Targets&IC50 | Ile107:23.8 nM , Asn107:22 nM |
In vivo | SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing[1].SHA 68 (i.v.; 1 mg/kg) has a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.SHA 68 (i.p.; 2.5 mg/kg) has a T1/2 of 0.43 hours, a CL of 4.56 mL/min/kg[1]. |
Molecular Weight | 445.49 |
Formula | C26H24FN3O3 |
CAS No. | 847553-89-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 250 mg/mL (561.18 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SHA 68 847553-89-3 G蛋白偶联受体 神经科学 Neuropeptide Y Receptor SHA-68 NPSR Ile107 SHA68 neuropeptide receptor NPSR BBB Inhibitor Asn107 NPY receptor inhibit non-peptide neuralgia inhibitor