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AR-M 1896 Acetate
AR-M 1896 Acetate is the selective agonist of GalR2.
Catalog No. T21646L
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Purity:99.76%
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AR-M 1896 Acetate
Catalog No. T21646LAlias AR-M 1896 Acetate (367518-31-8 Free base)
AR-M 1896 Acetate is the selective agonist of GalR2.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $565 | In Stock | |
| 2 mg | $765 | In Stock | |
| 5 mg | $1,120 | In Stock | |
| 10 mg | $1,530 | In Stock | |
| 25 mg | $2,260 | In Stock | |
| 50 mg | $2,970 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $2,330 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AR-M 1896 Acetate is the selective agonist of GalR2. |
| Targets&IC50 | GalR2:1.76 nM, GalR1 (human):879 Nm |
| In vitro | Removal of the glycine residue in position 1 resulted in AR-M1896 with almost unchanged GalR2 affinity and functional activity, and 500-fold selectivity for GalR2-Rs over GalR1-Rs[1].? |
| In vivo | In normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. The same effect is seen with equimolar doses of AR-M1896 or AR-M961 (an agonist both at GalR1 and GalR2 receptors). In allodynic Bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high AR-M961dose, whereas no effect was observed in the control or AR-M1896 group. No effect of either compounds was observed in nonallodynic Bennett model rats[1]. |
| Alias | AR-M 1896 Acetate (367518-31-8 Free base) |
| Molecular Weight | 1196.35 |
| Formula | C56H85N13O16 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/ml (45.97 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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