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SMP-028

Catalog No. T12936Cas No. 914389-14-3

SMP-028 is a neutral cholesterol esterase (CEase) inhibitor(IC50 : 1.01 μM).

SMP-028

SMP-028

Catalog No. T12936Cas No. 914389-14-3
SMP-028 is a neutral cholesterol esterase (CEase) inhibitor(IC50 : 1.01 μM).
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
SMP-028 is a neutral cholesterol esterase (CEase) inhibitor(IC50 : 1.01 μM).
Targets&IC50
CEase:1.01 μM
In vitro
SMP-028 potently inhibits neutral cholesterol esterase (CEase) with an IC50 of 1.01 μM in a concentration-dependent manner. However, it weakly inhibits other steroidogenic enzymes, with IC50 values >10 μM. Specifically, SMP-028 does not inhibit acid CEase and only weakly affects CYP11A1, with IC50 values >100 μM and 49.8 μM, respectively [1]. At concentrations of 10 μM or less, SMP-028 does not affect the viability of male adrenal cells, female adrenal cells, testicular cells, or ovarian cells, but concentrations above 30 μM significantly reduce the viability of male and female adrenal cells [2].
Chemical Properties
Molecular Weight455.55
FormulaC23H26FN5O2S
Cas No.914389-14-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SMP 028SMP-028SMP028
Related Tags: buy SMP-028 | purchase SMP-028 | SMP-028 cost | order SMP-028 | SMP-028 chemical structure | SMP-028 in vitro | SMP-028 formula | SMP-028 molecular weight
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