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TBK1/IKKε-IN-1

Catalog No. T13097   CAS 2058264-32-5

TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).

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TBK1/IKKε-IN-1 Chemical Structure
TBK1/IKKε-IN-1, CAS 2058264-32-5
Pack Size Availability Price/USD Quantity
25 mg 10-14 weeks $ 2,420.00
50 mg 10-14 weeks $ 3,180.00
100 mg 10-14 weeks $ 4,300.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
Targets&IC50 TBK1:100 nM, IKKε:100 nM
In vitro IKKε and TBK1 are serine/threonine kinases and are highly homologous to other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognized by Toll-like receptors 3 and 4 and RNA helicases RIG-1 and MDA-5, and lead to the activation of the TRIF-TBK1/IKKε-IRF3 signaling cascade, resulting in type I interferon. response.
Molecular Weight 498.53
Formula C28H26N4O5
CAS No. 2058264-32-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Brian A. Sherer, et al. Tbk/ikk inhibitor compounds and uses thereof. US 20160376283 A1.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TBK1/IKKε-IN-1 2058264-32-5 NF-Κb IκB/IKK TBK1/IKKε IN 1 TBK1/IKKεIN1 TBK-1/IKKε-IN-1 inhibitor inhibit

 

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