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TD-106

Name: TD-106
Brand: TargetMol
SKU: T13104
Rating: 4.5 (1 reviews)

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Catalog No. T13104Cas No. 2250288-69-6

TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.

TD-106

😃Good

Catalog No. T13104Cas No. 2250288-69-6

TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.

Pack Size	Price	Availability	Quantity
1 mL x 10 mM (in DMSO)	$318	7-10 days

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Product Introduction

Bioactivity

Description	TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
In vitro	TD-106 inhibits the proliferation of NCI-H929 myeloma cell line with an CC50?of?0.039?μM, and induces the degradation of IKZF1/3 in NCI-H929?cells.
In vivo	In SCID mice with TMD-8 xenograft model, TD-106 possesses anti-myeloma activity .

Chemical Properties

Molecular Weight	273.25
Formula	C₁₂H₁₁N₅O₃
Cas No.	2250288-69-6
Relative Density.	1.77 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (457.46 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6597 mL	18.2983 mL	36.5965 mL	182.9826 mL
5 mM	0.7319 mL	3.6597 mL	7.3193 mL	36.5965 mL
10 mM	0.3660 mL	1.8298 mL	3.6597 mL	18.2983 mL
20 mM	0.1830 mL	0.9149 mL	1.8298 mL	9.1491 mL
50 mM	0.0732 mL	0.3660 mL	0.7319 mL	3.6597 mL
100 mM	0.0366 mL	0.1830 mL	0.3660 mL	1.8298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TD-106TD106TD 106CRBN