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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $135 | In Stock | |
5 mg | $289 | In Stock | |
10 mg | $438 | In Stock | |
25 mg | $726 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,380 | In Stock | |
500 mg | $2,770 | In Stock | |
1 mL x 10 mM (in DMSO) | $373 | In Stock |
Description | TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease. |
In vitro | TXNIP-IN-1 bocks high glucose (HG induced) TXNIP-TRX complex formation.In monocytes, TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF . In THP1 cells,TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression . TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages. In MIN6 cells, TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels . TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in human pancreas 1.1B4 beta cells. TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose. TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets. |
Molecular Weight | 248.23 |
Formula | C12H12N2O4 |
Cas No. | 1268955-50-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (161.14 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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