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VU 6008667

Name: VU 6008667
Brand: TargetMol
SKU: T13315
Price: 27 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T13315Cas No. 2092923-21-0

VU 6008667 is a selective negative allosteric modulator (NAM) of the M5 receptor, with IC50 values of 1.2 μM for human M5 and 1.6 μM for rat M5.

VU 6008667

😃Good

Catalog No. T13315Cas No. 2092923-21-0

VU 6008667 is a selective negative allosteric modulator (NAM) of the M5 receptor, with IC50 values of 1.2 μM for human M5 and 1.6 μM for rat M5.

Pack Size	Price	Availability
25 mg	$854	6-8 weeks
50 mg	$1,110	6-8 weeks
100 mg	$1,860	6-8 weeks

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Product Introduction

Bioactivity

Description	VU 6008667 is a selective negative allosteric modulator (NAM) of the M5 receptor, with IC50 values of 1.2 μM for human M5 and 1.6 μM for rat M5.
Targets&IC50	M5 (human):1.2 μM , M5 (rat):1.6 μM

Chemical Properties

Molecular Weight	438.85
Formula	C₂₄H₁₇ClF₂N₂O₂
Cas No.	2092923-21-0
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (227.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2787 mL	11.3934 mL	22.7868 mL	113.9341 mL
5 mM	0.4557 mL	2.2787 mL	4.5574 mL	22.7868 mL
10 mM	0.2279 mL	1.1393 mL	2.2787 mL	11.3934 mL
20 mM	0.1139 mL	0.5697 mL	1.1393 mL	5.6967 mL
50 mM	0.0456 mL	0.2279 mL	0.4557 mL	2.2787 mL
100 mM	0.0228 mL	0.1139 mL	0.2279 mL	1.1393 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VU-6008667VU6008667VU 6008667Rat M5Human M5