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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $50 | In Stock | |
50 mg | $72 | In Stock | |
100 mg | $109 | In Stock | |
200 mg | $197 | In Stock |
Description | WST-8 is a water-soluble tetrazolium dye, the sensitivity of the WST-8(WST8)-based assay is higher than the conventional MTS-based assay. |
In vivo | NS1209 could be safely administered to rats undergoing electrically induced SE at doses up to 50 mg/kg followed by intravenous infusion of 5 mg/kg for up to 24h. NS1209 administered as a bolus dose of 10-50 mg/kg (i.p. or i.v.) followed by infusion of 4 or 5 mg/kg h (i.v.) for 2-24h effectively discontinued electrically induced SE in all animals within 30-60 min, and there was no recurrence of SE after a 24-h infusion. Kainate-induced SE was similarly blocked by 10 or 30 mg/kg NS1209 (i.v.). To compare the efficacy and neuroprotective effects of NS1209 with those of diazepam (DZP), one group of rats received DZP (20 mg/kg, i.p. and another dose of 10 mg/kg 6h later). By using the administration protocols described, the anticonvulsant effect of NS1209 was faster and more complete than that of DZP. NS1209 treatment (20 mg/kg bolus followed by 5 mg/kg h infusion for 24 h) was neuroprotective against SE-induced hippocampal neurodegeneration, but to a lesser extent than DZP. |
Alias | WST8 |
Molecular Weight | 600.47 |
Formula | C20H13N6NaO11S2 |
Cas No. | 193149-74-5 |
Storage | keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | H2O: 50 mg/mL (83.13 mM) DMSO: 50 mg/mL (83.13 mM) ![]() | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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