(+)-Coclaurine hydrochloride, also known as (+)-(R)-Coclaurine, is a benzyltetrahydroisoquinoline alkaloid extracted from multiple plant species. This compound exhibits anti-aging properties, as reported in sources [1] [2].

Intracerebroventricular administration of (+)-Coclaurine (d-Coclaurine; 50 μg) hydrochloride results in a modest elevation of 3,4-dihydroxyphenylacetic acid and a pronounced rise in homovanillic acid in the mouse striatum. Notably, (+)-Coclaurine hydrochloride selectively antagonizes postsynaptic dopamine receptors without affecting the presynaptic counterparts in the mouse striatum [2].