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A-317567
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Catalog No. T14070Cas No. 371217-32-2
A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, exhibiting antidepressant and antinociceptive effects[1][2].
A-317567
😃Good
Catalog No. T14070Cas No. 371217-32-2
A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, exhibiting antidepressant and antinociceptive effects[1][2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,620 | 10-14 weeks | |
| 50 mg | $2,110 | 10-14 weeks | |
| 100 mg | $3,150 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, exhibiting antidepressant and antinociceptive effects[1][2]. |
| Targets&IC50 | ASIC3:1.025 μM |
| In vitro | The effects of A-317567 on three distinct types of native ASIC currents evoked in acutely dissociated adult rat dorsal root ganglion (DRG) neurons are studied. A-317567 equipotently blocks the sustained phase of ASIC3-like current, a biphasic current akin to cloned ASIC3, which is predominant in DRG[2]. A-317567 produces concentration-dependent inhibition of all pH 4.5-evoked ASIC currents with an IC50 ranging between 2 and 30 μM, depending upon the type of ASIC current activated. |
| In vivo | A-317567 is fully analgesic effects in the CFA model (ED50 of 17 μmol/kg, i.p., adult male Sprague-Dawley rats) and it has no significant effect on the withdrawal latency of the contralateral paw under these conditions[2]. |
| Molecular Weight | 397.56 |
| Formula | C27H31N3 |
| Cas No. | 371217-32-2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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