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A011
Catalog No. T78711
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1].
A011
A011
Catalog No. T78711
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $143 | 35 days | |
| 5 mg | $668 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1]. |
| Targets&IC50 | ATM:1.0 nM |
| In vitro | Compound A011 (compound 8d) at concentrations of 10, 30, and 100 nM applied for 5 days increases the sensitivity of SW620 and HCT116 cells to CPT-11 (100 nM) [1]. When administered in conjunction with CPT-11 at doses ranging from 0 to 100 nM for 24 and 72 hours, A011 induces apoptosis and cell cycle arrest at the G2/M phase [1]. Furthermore, A011 at concentrations of 3, 9, 27, 83, and 250 nM reduces the expression of p-ATM and p-Chk2 in a dose-dependent manner in SW620 cells under irradiation conditions of 1.5 or 3 Gy [1]. |
| In vivo | A011 (5 mg/kg; intraperitoneal injection; daily for 23 days) combined with CPT-11 (5 mg/kg, intraperitoneal injection; once weekly) demonstrated antitumor activity in mice [1]. |
| Molecular Weight | 452.55 |
| Formula | C27H28N6O |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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