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Ac-Gly-BoroPro

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Catalog No. T10227Cas No. 886992-99-0

Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.

Ac-Gly-BoroPro

Ac-Gly-BoroPro

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Catalog No. T10227Cas No. 886992-99-0
Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.
Targets&IC50
FAP:ki:23 nM
In vitro
Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady-state inhibition levels rapidly (Ki: 23 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady-state inhibition levels (Ki=377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with Ki values ranging from 9- to 5400-fold higher than that for FAP inhibition.
Kinase Assay
Ki values for inhibition of proteases by Ac-Gly-BoroPro are determined using the method of progress curves for analysis of tight-binding competitive inhibitors. Various concentrations of Ac-Gly-BoroPro are reacted with FAP (1.0 nM) and DPP-4 (0.1 nM) in the presence of Ala-Pro-AFC (500 μM for FAP; 100 μM for DPP-4), and time-dependent inhibition of each protease is monitored. Reactions contained inhibitor concentrations at least 20-fold greater than protease concentrations, such that the protease-inhibitor complex does not significantly deplete the free inhibitor.
Chemical Properties
Molecular Weight214.03
FormulaC8H15BN2O4
Cas No.886992-99-0
Relative Density.1.26 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (233.61 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.6722 mL23.3612 mL46.7224 mL233.6121 mL
5 mM0.9344 mL4.6722 mL9.3445 mL46.7224 mL
10 mM0.4672 mL2.3361 mL4.6722 mL23.3612 mL
20 mM0.2336 mL1.1681 mL2.3361 mL11.6806 mL
50 mM0.0934 mL0.4672 mL0.9344 mL4.6722 mL
100 mM0.0467 mL0.2336 mL0.4672 mL2.3361 mL

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