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Acetoacetic acid sodium salt

Acetoacetic acid sodium salt
Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes.
Catalog No. T13528Cas No. 623-58-5
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Purity:≥98%
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Acetoacetic acid sodium salt

Catalog No. T13528Cas No. 623-58-5
Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
2 mg$59In Stock
5 mg$97In Stock
10 mg$147In Stock
25 mg$240In Stock
50 mg$360In Stock
100 mg$535In Stock
500 mg$1,160In Stock
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Other Forms of Acetoacetic acid sodium salt:
Acetoacetic acidT73734541-50-4
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Product Introduction

Bioactivity
Description
Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes.
In vitro
Acetoacetic acid sodium salt triggers oxidative stress, thereby impeding very-low-density lipoprotein (VLDL) assembly in bovine hepatocytes. This compound, at concentrations of 0.6, 2.4, and 4.8 mM, increases malondialdehyde (MDA) content in the high-dose group (GH), diminishes mRNA levels of Mn-SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) across all groups, and reduces catalase (CAT) mRNA expression in the medial-dose (GM) and GH groups. Furthermore, it suppresses mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and the low-density lipoprotein receptor (LDLR), leading to reduced VLDL assembly and heightened triglyceride (TG) accumulation in bovine hepatocytes.
Chemical Properties
Molecular Weight124.07
FormulaC4H5NaO3
Cas No.623-58-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (403.00 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM8.0600 mL40.2998 mL80.5997 mL402.9983 mL
5 mM1.6120 mL8.0600 mL16.1199 mL80.5997 mL
10 mM0.8060 mL4.0300 mL8.0600 mL40.2998 mL
20 mM0.4030 mL2.0150 mL4.0300 mL20.1499 mL
50 mM0.1612 mL0.8060 mL1.6120 mL8.0600 mL
100 mM0.0806 mL0.4030 mL0.8060 mL4.0300 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

inhibitAcetoacetic acid sodium saltEndogenous MetaboliteAcetoacetic acid sodiumInhibitorAcetoacetic acid
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