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ACT-389949

Name: ACT-389949
Brand: TargetMol
SKU: T10242
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10242Cas No. 1258417-54-7

ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of inflammatory disorders.

ACT-389949

🥰Excellent

Purity: 99.40%

Catalog No. T10242Cas No. 1258417-54-7

Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$147	In Stock
10 mg	$226	In Stock
25 mg	$397	In Stock
50 mg	$592	In Stock
100 mg	$888	In Stock

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Purity:99.40%

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COA HNMR LCMS

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Product Introduction

Bioactivity

Description	ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of inflammatory disorders.
Targets&IC50	FPR2/ALX:3 nM(EC50)
In vivo	ACT-389949 demonstrates a favorable tolerance profile. Peak concentration levels occur approximately 2 hours post-administration, and it exhibits a mean terminal half-life of 29.3 hours. The administration of ACT-389949 induces a dose-dependent, prolonged internalization of FPR2/ALX within leukocytes [1].

Chemical Properties

Molecular Weight	428.39
Formula	C₂₀H₁₈F₂N₆O₃
Cas No.	1258417-54-7
Smiles	Cc1nc(C(=O)Nc2cnn(Cc3nc(co3)C(C)(F)F)n2)c(o1)-c1cccc(C)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 10 mg/mL (23.34 mM), when pH is adjusted to 1 with HCl. Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3343 mL	11.6716 mL	23.3432 mL	116.7161 mL
5 mM	0.4669 mL	2.3343 mL	4.6686 mL	23.3432 mL
10 mM	0.2334 mL	1.1672 mL	2.3343 mL	11.6716 mL
20 mM	0.1167 mL	0.5836 mL	1.1672 mL	5.8358 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ACT-389949inhibitACT389949ACT 389949Inhibitor