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ADU-S100

Catalog No. T10252L3Cas No. 1638241-89-0

ADU-S100 is an activator of stimulator of interferon genes (STING).

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Pack Size	Price	Availability
25 mg	Inquiry	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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Product Introduction

Bioactivity

Description	ADU-S100 is an activator of stimulator of interferon genes (STING).
In vitro	ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP[1].
In vivo	A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%[1].
Alias	ML RR-S2 CDA, MIW815

Chemical Properties

Molecular Weight	690.54
Formula	C20H24N10O10P2S2
Cas No.	1638241-89-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (72.41 mM)

DMSO: 2 mg/mL (2.90 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4481 mL	7.2407 mL	14.4814 mL	72.4071 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.2896 mL	1.4481 mL	2.8963 mL	14.4814 mL
10 mM	0.1448 mL	0.7241 mL	1.4481 mL	7.2407 mL
20 mM	0.0724 mL	0.3620 mL	0.7241 mL	3.6204 mL
50 mM	0.0290 mL	0.1448 mL	0.2896 mL	1.4481 mL
100 mM	0.0145 mL	0.0724 mL	0.1448 mL	0.7241 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc