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ADU-S100

Name: ADU-S100
Brand: TargetMol
SKU: T10252L3
Price: 94 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T10252L3Cas No. 1638241-89-0

Alias ML RR-S2 CDA, MIW815

ADU-S100 is an activator of stimulator of interferon genes (STING).

ADU-S100

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Catalog No. T10252L3Alias ML RR-S2 CDA, MIW815Cas No. 1638241-89-0

ADU-S100 is an activator of stimulator of interferon genes (STING).

Pack Size	Price	Availability
25 mg	Inquiry	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	ADU-S100 is an activator of stimulator of interferon genes (STING).
In vitro	ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP[1].
In vivo	A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%[1].
Alias	ML RR-S2 CDA, MIW815

Chemical Properties

Molecular Weight	690.54
Formula	C₂₀H₂₄N₁₀O₁₀P₂S₂
Cas No.	1638241-89-0
Relative Density.	2.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 50 mg/mL (72.41 mM), Sonication is recommended.

DMSO: 2 mg/mL (2.90 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.4481 mL	7.2407 mL	14.4814 mL	72.4071 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.2896 mL	1.4481 mL	2.8963 mL	14.4814 mL
10 mM	0.1448 mL	0.7241 mL	1.4481 mL	7.2407 mL
20 mM	0.0724 mL	0.3620 mL	0.7241 mL	3.6204 mL
50 mM	0.0290 mL	0.1448 mL	0.2896 mL	1.4481 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

STINGMIW-815MIW 815ADU-S-100ADU-S100ADUS100ADU-S 100ADU S100