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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $159 | In Stock | |
5 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | Inquiry | In Stock |
Description | ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity. |
In vitro | ADU-S100 ammonium salt induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 ammonium salt is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage. ADU-S100 ammonium salt induces significantly higher levels of IFN-α compared to ML cGAMP[1]. |
In vivo | IT injection of ADU-S100 ammonium salt into one tumor in BALB/c mice bearing bilateral CT26 or 4T1 tumors also demonstrated significant regression of the contralateral, untreated tumor. IT injection with ADU-S100 ammonium salt eradicates multiple tumor types and primes an effective systemic CD8+ T cell immune response that significantly inhibits the growth of distal, untreated lesions[1]. |
Alias | ML RR-S2 CDA ammonium salt, MIW815 ammonium salt |
Molecular Weight | 724.6 |
Formula | C20H30N12O10P2S2 |
Cas No. | 1638750-96-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | H2O: 5 mg/mL (6.90 mM), Sonication is recommended. DMSO: 12 mg/mL (16.58 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O/DMSO
DMSO
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