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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $175 | In Stock | |
5 mg | $372 | In Stock | |
10 mg | $619 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,370 | In Stock | |
100 mg | $1,850 | In Stock | |
1 mL x 10 mM (in DMSO) | $655 | In Stock |
Description | diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist. |
In vitro | Activation of diABZI STING agonist-1 trihydrochloride elicits a type-I interferon response that propagates interferon receptor signalling in tumour-resident dendritic cells and leads to antitumour CD8+ T cell responses in vivo. |
Animal Research | To evaluate the potential therapeutic effects of systemically administered diABZI STING agonist-1 trihydrochloride, tested the efficacy of intravenously delivered diABZI STING in a syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.?We first established the pharmacokinetic profile of STING in BALB/c mice following intravenous injection of 3 mg/kg .?STING exhibited systemic exposure with a half-life of 1.4 h and achieved systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml).?Next, we tested an intermittent dosing paradigm in which 1.5 mg/kg STING was injected intravenously on days 1, 4, and 8 in mice with approximately 100 mm^3 subcutaneous CT-26 tumours.?Treatment with STING resulted in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improved survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43. |
Molecular Weight | 959.32 |
Formula | C42H54Cl3N13O7 |
Cas No. | 2138299-34-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (130.30 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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