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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $1,650 | In Stock | |
5 mg | $3,280 | In Stock | |
25 mg | $7,630 | In Stock |
Description | Dazostinag disodium (TAK-676) is a novel stimulator of interferon genes (STING) agonist and immune system modulator with antitumor activity that activates dendritic cells, natural killer cells, and T cells. |
In vitro | In THP1-Dual human acute myeloid leukemia cells and CT26.WT cells, treatment with Dazostinag disodium (1.1, 3.3, 10 μM; 2 hours) resulted in a dose-dependent increase in the protein levels of pTBK1, pSTING, and pIRF3. In the absence of STING expression, no induction of phosphorylation of pTBK1 (S172) or pIRF3 (S396) was observed[1]. |
In vivo | In BALB/c mice bearing A20 syngeneic tumors CT26.WT syngeneic tumors model, treatment with Dazostinag disodium (1 or 2 mg/kg/day; Intravenous injection; 3, 6, 9, 12 days) resulted in significant T cell-dependent in vivo antitumor activity, as well as activation and proliferation of immune cells within the tumor microenvironment and tumor-associated lymphoid tissue[1]. |
Molecular Weight | 754.48 |
Formula | C21H20F2N8Na2O10P2S2 |
Cas No. | 2553413-93-5 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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