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diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

Nerisopam is an agonist of gamma-aminobutyric acid (GABA) receptor.

Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins.

Silperisone HCl (RGH-5002) blocks sodium and calcium channels in cells, decreases excitability and contractility of muscle cells, reduces peripheral tone, and acts as a muscle relaxant and peripheral vasodilator. Silperisone HCl is used to treat recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, dystonia symptoms, cone tension syndrome, multiple sclerosis myospasm and myelitis. silperisone is a sodium channel protein type 2 alpha channel blocker. silperisone is an organosilicon similar to tolperisone, an organosilicon compound with centrally acting muscle relaxant properties.

Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.

Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.

MSA-2 is a potent and orally available non-nucleotide STING agonist.

SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a closed activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.

H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.

C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor

Perisesaccharide C is a natural product

Monnierisides A, a chromone glycoside, has been isolated from Cnidium monnieri [1].

Perisesaccharide B is a natural product

Pterisolic acid F is a natural product from Pteris semipinnata.

Pierisformoside B is a useful organic compound for research related to life sciences. The catalog number is T125082 and the CAS number is 308335-44-6.

Perisulfakinin, a satiety-signaling neuropeptide, suppresses the activity of neurons that stimulate general activity [1].

6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, exhibits cytotoxicity against HL-60 and MOLT-3 leukemia cell lines, demonstrating half maximal inhibitory concentrations (IC50s) ranging from 4.1 to 5.4 μM [1].

Eperisone is a centrally acting muscle relaxant and antispastic agent utilized in the treatment of conditions distinguished by muscle stiffness and pain. Its mechanism of action involves the relaxation of skeletal muscles and vascular smooth muscles, resulting in a range of beneficial effects including reduction of myotonia, enhancement of circulation, and suppression of the pain reflex. Additionally, Eperisone exhibits inhibitory properties on the pain reflex pathway and exerts a vasodilator effect.

SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.

Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924.

Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity.

Asteriscunolide A is a useful organic compound for research related to life sciences and the catalog number is T124126.

Monnieriside A is a useful organic compound for research related to life sciences and the catalog number is T125921.

Lanperisone is a muscle relaxant.

Monnieriside G is a natural product from Cnidium monnieri.

Inaperisone is a novel centrally acting muscle relaxant that inhibits the voiding reflex. Inaperisone may inhibit the voiding reflex by acting indirectly on GABAB receptors in the brainstem.

Acetyl Perisesaccharide C is a natural product

Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyelitis, myelopathy, multiple sclerosis, pyramidal tract) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.

Pterisolic acid C is a natural product from Pteris semipinnata.

Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a

Pterisolic acid A shows moderate activity against HCT-116,Hep G2 and BGC-823 cell lines.

Lanperisone HCl (NK 433) is a novel orally available centrally acting muscle relaxant with anticancer activity and inhibits mono- and polysynaptic reflex potentials.Lanperisone HCl acts by inducing non-apoptotic cell death in the cell cycle and translational independence.

Enerisant (TS-091) is an orally active, selective and potent histamine H3 receptor antagonist that modulates histamine H3 receptors in mice in a dose-dependent manner.Enerisant promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.

Pterisolic acid E is a natural product from Pteris semipinnata.

Pterisolic acid D is a natural product for research related to life sciences. The catalog number is TN4845 and the CAS number is 1401419-88-2.

Eperisone is a skeletal muscle relaxant and a spasmolytic agent related structurally to Tolperisone.

Nerispirdine is a biochemical that inhibits batrachotoxin binding to voltage-dependent sodium channels.

Tolperisone free base, a centrally acting muscle relaxant, has been used for the symptomatic treatment of spasticity and muscle spasm.

diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.

STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.

CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.

STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.

STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).

C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.

ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory Factor (IRF) 3.

STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.

SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.

STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.