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STING agonist-4

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Catalog No. T13015Cas No. 2138300-40-8

STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).

STING agonist-4

STING agonist-4

😃Good
Catalog No. T13015Cas No. 2138300-40-8
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).
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Purity:≥98%
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Product Introduction

Bioactivity
Description
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
Targets&IC50
STING agonist-4:20 nM
In vitro
STING agonist-4 (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (0.001 nM-1 μM) inhibits the binding of full-length STING to the solid support (Kd: 1.6 nM). STING agonist-4 (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand)(EC50 of 53.9 μM). STING agonist-4 (3 μM; 4 hours) promotes the production of interferon γ-induced protein 10 (IP-10), IL-6, and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.
Chemical Properties
Molecular Weight678.74
FormulaC34H38N12O4
Cas No.2138300-40-8
SmilesCCn1nc(C)cc1C(=O)Nc1nc2cc(ccc2n1CCCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(ccc12)C(N)=O)C(N)=O
Relative Density.1.48 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (14.73 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4733 mL7.3666 mL14.7332 mL73.6659 mL
5 mM0.2947 mL1.4733 mL2.9466 mL14.7332 mL
10 mM0.1473 mL0.7367 mL1.4733 mL7.3666 mL

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