Shopping Cart
- Remove All
Your shopping cart is currently empty
diABZI STING agonist-1
🥰Excellent
Catalog No. T73746Cas No. 2138299-33-7
diABZI STING agonist-1 is a selective and potent interferon gene-stimulating receptor (STING) agonist with potential antitumor and anti-inflammatory activity for the study of cancer.
diABZI STING agonist-1
🥰Excellent
Purity: 98.29%
Catalog No. T73746Cas No. 2138299-33-7
diABZI STING agonist-1 is a selective and potent interferon gene-stimulating receptor (STING) agonist with potential antitumor and anti-inflammatory activity for the study of cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $148 | In Stock | |
| 5 mg | $372 | In Stock | |
| 10 mg | $619 | In Stock | |
| 25 mg | $965 | In Stock | |
| 50 mg | $1,280 | In Stock | |
| 100 mg | $1,750 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "diABZI STING agonist-1"
Dazostinag disodium
T724822553413-93-5In house
Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist that triggers STING signaling pathway activation and type I interferon activation. Dazostinag disodium (TAK-676) is also a highly effective immune system modulator with complete resolution and lasting memory of T cell immunity and the ability to promote lasting interferon-dependent anti-tumor immune responses.
- $1,650
Size
QTY
H-151
Cited
T5674941987-60-6
H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.
- $30
Size
QTY
CitedSR-717
T86552375421-09-1
SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.
- $75
Size
QTY
CCCP Cited
Carbonyl Cyanide m-Chlorophenylhydrazone, Carbonyl cyanide 3-chlorophenylhydrazone
T7081555-60-2
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
- $41
Size
QTY
CitedSN-008
T95542249106-01-0In house
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
- $56
Size
QTY
C-178
T7329329198-87-0
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
- $37
Size
QTY
C-176 Cited
STING inhibitor 1, C176
T5154314054-00-7
C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNβ production and possesses anti-inflammatory activity.
- $30
Size
QTY
CitedMSA-2
T8798129425-81-6
MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3]
- $34
Size
QTY
Cridanimod
XBIO-101, CMA, 10-carboxymethyl-9-acridanone
T531738609-97-1
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
- $30
Size
QTY
T55162138299-34-8In house
diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.
- $175
Size
QTY
CitedVadimezan Cited
NSC 640488, DMXAA, ASA-404, 5,6-Dimethylxanthenone-4-acetic Acid
T6273117570-53-3
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.
- $48
Size
QTY
CitedSelect Batch
Purity:98.29%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | diABZI STING agonist-1 is a selective and potent interferon gene-stimulating receptor (STING) agonist with potential antitumor and anti-inflammatory activity for the study of cancer. |
| In vivo | In Wild and Sting −/− C57Blk6 mice, diABZI STING agonist-1 ( 2.5 mg/kg ; subcutaneous injection ; 2.5 mg/kg ) activated secretion of IFNβ, IL-6, TNF, and CXCL1 in wild-type but not Sting −/− mice[1]. |
| Molecular Weight | 849.94 |
| Formula | C42H51N13O7 |
| Cas No. | 2138299-33-7 |
| Smiles | O=C(C1=CC(C)=NN1CC)N=C2N(C3=C(OC)C=C(C(N)=O)C=C3N2)C/C=C/CN4C5=C(OCCCN6CCOCC6)C=C(C(N)=O)C=C5NC4=NC(C7=CC(C)=NN7CC)=O |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (Insoluble) DMSO: 80 mg/mL (94.12 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy diABZI STING agonist-1 | purchase diABZI STING agonist-1 | diABZI STING agonist-1 cost | order diABZI STING agonist-1 | diABZI STING agonist-1 chemical structure | diABZI STING agonist-1 in vivo | diABZI STING agonist-1 formula | diABZI STING agonist-1 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.