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Alvimopan dihydrate (LY246736 dihydrate)
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Catalog No. T22238Cas No. 170098-38-1
Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active, and reversible μ-opioid receptor antagonist with an IC50 of 1.7 nM. Highly selective for the μ-opioid receptor (Ki = 0.47 nM) over κ- and δ-opioid receptors (Kis = 100 and 12 nM, respectively), Alvimopan dihydrate can be used for research on postoperative ileus [1] [2] [3].
Alvimopan dihydrate (LY246736 dihydrate)
😃Good
Catalog No. T22238Cas No. 170098-38-1
Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active, and reversible μ-opioid receptor antagonist with an IC50 of 1.7 nM. Highly selective for the μ-opioid receptor (Ki = 0.47 nM) over κ- and δ-opioid receptors (Kis = 100 and 12 nM, respectively), Alvimopan dihydrate can be used for research on postoperative ileus [1] [2] [3].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $52 | 5 days |
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Bioactivity
Chemical Properties
| Description | Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active, and reversible μ-opioid receptor antagonist with an IC50 of 1.7 nM. Highly selective for the μ-opioid receptor (Ki = 0.47 nM) over κ- and δ-opioid receptors (Kis = 100 and 12 nM, respectively), Alvimopan dihydrate can be used for research on postoperative ileus [1] [2] [3]. |
| In vitro | Alvimopan inhibits the binding of loperamide-stimulated [35 S]GTPγS to membranes containing the cloned human μ-opioid receptor with an IC 50 of 1.7 nM [1]. |
| In vivo | Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the morphine-induced slowing of small intestinal transit of ^113Sn-labelled microspheres in rats, whereas Alvimopan (3 mg/kg; p.o.) has no effect on noxious colorectal distension (CRD)-induced visceromotor behavioral responses (VMR) in conscious rats [3]. |
| Molecular Weight | 460.56 |
| Formula | C25H36N2O6 |
| Cas No. | 170098-38-1 |
| Relative Density. | 1.166g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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