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AMP-PNP tetralithium

Name: AMP-PNP tetralithium
Brand: TargetMol
SKU: T37733
Rating: 4.5 (1 reviews)

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Catalog No. T37733Cas No. 72957-42-7

Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

AMP-PNP tetralithium

😃Good

Catalog No. T37733Cas No. 72957-42-7

Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	35 days

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Product Introduction

Bioactivity

Description

Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.
Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID:2412134 |Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID:4326768 |Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 23 231 PMID:7805625

Chemical Properties

Molecular Weight	529.93
Formula	C₁₀H₁₃Li₄N₆O₁₂P₃
Cas No.	72957-42-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 26.5 mg/mL (50.01 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.8870 mL	9.4352 mL	18.8704 mL	94.3521 mL
5 mM	0.3774 mL	1.8870 mL	3.7741 mL	18.8704 mL
10 mM	0.1887 mL	0.9435 mL	1.8870 mL	9.4352 mL
20 mM	0.0944 mL	0.4718 mL	0.9435 mL	4.7176 mL
50 mM	0.0377 mL	0.1887 mL	0.3774 mL	1.8870 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

AMP-PNPAMP PNP tetralithiumAMP-PNP tetralithiumAMPPNP tetralithium