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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Antibacterial agent 140 chloride, a first-of-its-kind Ru-based AIEgen photosensitizer, shows promise in detecting and treating Gram-positive bacteria (G+). It effectively discriminates against and exterminates G+ by interacting with lipoteichoic acids (LTA), displaying robust antibacterial activity under light irradiation [1]. |
In vitro | Antibacterial agent 140 chloride (0.1-5 µg/mL, 1 h) demonstrated dose-dependent dark toxicity with a 78%-0% inhibition against S. aureus [1]. Upon exposure to light for 120s, a clear dose- and time-dependent effect was observed, as Ru2 nearly completely inhibited the growth of Staphylococcus aureus at extremely low concentrations [1]. Furthermore, more than 80% of HeLa cells survived after incubation with antibacterial agent 140 chloride (0.1-5 µg/mL, 1 h), and over 73% of HeLa cells remained viable under light conditions ≤32 µM [1]. |
In vivo | Antibacterial agent 140 chloride (20 μg/mL/50 μL; 1-10 days) significantly reduced the size of Staphylococcus aureus-induced wound infections, with wounds in female Kunming mice nearly fully healed after 7 days. |
Molecular Weight | 1162.1 |
Formula | C61H44Cl2N8Ru2- |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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