Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent.

Antibacterial agent 60 (example 26) significantly reduces the Minimum Inhibitory Concentration (MIC) values for Ceftazidime, enhancing its antibacterial efficacy against various E. coli strains (MIC=1, 1, 8 mcg/ml for NCTC 1335 1, M50, and 7MP, respectively). Similarly, Antibacterial agent 58 markedly lowers the MIC values of Ceftazidime across different ESBL classes: 0.25-4 mcg/ml for Class A ESBL (E. coli strains W 13353, W3351, and W 13352); 1-8 mcg/ml for Class C ESBL (E. coli strains M 50, 7 MIP, and B 89); 1-4 mcg/ml for KPC ESBL (K. pneumoniae strains H 520, H 521, and H 522); and showing strong activity against Class D ESBL strains A. baumannii 13301 and A. baumannii 13304 with MIC values of 16 and >32 respectively [From WO2013030735A1, example 26].