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Antiproliferative agent-17
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Catalog No. T72204Cas No. 2882206-08-6
Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].
Antiproliferative agent-17
😃Good
Catalog No. T72204Cas No. 2882206-08-6
Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1]. |
| In vitro | Antiproliferative agent-17 (compound 5e) exhibited activity against Gram-positive bacteria, including Staphylococcus aureus IFO 3060, Bacillus subtilis IFO 3007, and Micrococcus luteus IFO 3232, but showed no activity against tested Gram-negative bacteria and fungi [1]. It demonstrated antiproliferative effects with IC50 values of 12.85 μM for PC-3 (human prostate cancer), 11.96 μM for HCT-116 (human colorectal cancer), 16.30 μM for HepG-2 (human hepatocellular carcinoma), 9.87 μM for HeLa (human cervical cancer), and 6.90 μM for MCF-7 (human breast cancer) [1]. Additionally, it binds to the active site of the SIRT1 enzyme, occupying the positions of the NAD cofactor and the known histone deacetylase inhibitor EX527 [1]. |
| Molecular Weight | 416.58 |
| Formula | C26H28N2OS |
| Cas No. | 2882206-08-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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