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Antiproliferative agent-18
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Catalog No. T75014Cas No. 2882206-14-4
Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1].
Antiproliferative agent-18
Antiproliferative agent-18
😃Good
Catalog No. T75014Cas No. 2882206-14-4
Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1]. |
| In vitro | Antiproliferative agent-18 (Compound 5k) demonstrated moderate antibacterial activity (inhibition zones of 14-17 mm) at 200 µg/8 mm disc over 24 h against bacteria and 48 h for fungi, with similar moderate activity against Candida albicans (inhibition zone of 17 mm) [1]. Additionally, it exhibited antiproliferative effects on human cancer cell lines including prostate (PC-3), colorectal (HCT-116), hepatocellular (HepG-2), epidermoid cervical (HeLa), and breast (MCF-7) at concentrations of 0.1-100 μM over 48 hours [1]. Antiproliferative agent-18 also occupied the active site of the SIRT1 enzyme, replacing the NAD cofactor and the histone deacetylase inhibitor EX527 [1]. |
| Molecular Weight | 434.57 |
| Formula | C26H27FN2OS |
| Cas No. | 2882206-14-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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