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As-358 hydrochloride
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Catalog No. T60959Cas No. 2374723-26-7
As-358 (hydrochloride) shows well in vivo safety as well as inhibits Ebola virus and Marburg virus with IC 50 values of 9.1 μM and 18.1 μM [1].
As-358 hydrochloride
😃Good
Catalog No. T60959Cas No. 2374723-26-7
As-358 (hydrochloride) shows well in vivo safety as well as inhibits Ebola virus and Marburg virus with IC 50 values of 9.1 μM and 18.1 μM [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | As-358 (hydrochloride) shows well in vivo safety as well as inhibits Ebola virus and Marburg virus with IC 50 values of 9.1 μM and 18.1 μM [1]. |
| In vitro | As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) demonstrates inhibitory effects on both EBOV and MARV [1]. In a cell proliferation assay on Vero cells infected with EBOV and MARV, it exhibited significant inhibition over 10 days. The IC50 values were 18.1 ± 9.3 μM for EBOV and 9.1 ± 2.1 μM for MARV, with selectivity index (SI) values of 15 and 31, respectively. |
| In vivo | As-358 (hydrochloride) administered intragastrically at dosages of 0.14-1.08 g/kg in a single dose demonstrated no toxicity in adult ICR mice [1]. The study employed a single-dose (IG; single) observational method over a 7-day period, revealing that the LD50 exceeds 1000 mg/kg, indicating its safety at these concentrations. |
| Molecular Weight | 329.91 |
| Formula | C18H32ClNO2 |
| Cas No. | 2374723-26-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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