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AS-85
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Catalog No. T39861Cas No. 2323623-80-7
Alias AS85
AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia.
AS-85
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Purity: 98.96%
Catalog No. T39861Alias AS85Cas No. 2323623-80-7
AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $139 | In Stock | |
| 5 mg | $413 | 7-10 days | |
| 10 mg | $689 | 7-10 days | |
| 25 mg | $1,490 | 7-10 days | |
| 50 mg | $2,380 | 7-10 days | |
| 100 mg | $3,790 | 7-10 days |
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Purity:98.96%
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Product Introduction
Bioactivity
Chemical Properties
| Description | AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia. |
| Targets&IC50 | ASH1L histone methyltransferase:0.6 µM, SET domain of ASH1L:0.78 µM (Kd) |
| In vitro | AS-85 is a potent inhibitor of ASH1L histone methyltransferase with an IC50 of 0.6 µM and significant antileukemic activity.AS-85 binds tightly to the SET domain of ASH1L with a Kd value of 0.78 µM. AS-85 inhibits the proliferation of leukemia cells harboring different MLL1 translocations such as MV4;11, MOLM13 and KOPN8. AS-85 inhibited the proliferation of leukemia cells carrying different MLL1 translocations (e.g. MV4;11, MOLM13 and KOPN8) with GI50 values ranging from 5 µM to 25 µM, but did not have a significant effect on K562 leukemia cells without the MLL1 translocation. [1] |
| Alias | AS85 |
| Molecular Weight | 579.66 |
| Formula | C26H28F3N5O3S2 |
| Cas No. | 2323623-80-7 |
| Smiles | O=C(NCC=1C=CC=2C(=CN(C2C1)C3CCN(CC3)S(=O)(=O)C(F)(F)F)C=4C=CC=C(C4)C(=S)N)C5CNC5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (138.01 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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