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AS-85

Catalog No. T39861 CAS 2323623-80-7

AS-85, a potent inhibitor of ASH1L histone methyltransferase (IC50 = 0.6 μM), exhibits anti-leukemic activity by strongly binding to the ASH1L SET domain (Kd = 0.78 μM).

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AS-85, CAS 2323623-80-7

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	AS-85, a potent inhibitor of ASH1L histone methyltransferase (IC50 = 0.6 μM), exhibits anti-leukemic activity by strongly binding to the ASH1L SET domain (Kd = 0.78 μM).
In vitro	AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI 50 values ranging from 5?μM to 25?μM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations[1].

Molecular Weight	579.66
Formula	C26H28F3N5O3S2
CAS No.	2323623-80-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. David S. Rogawski, Jing Deng, Hao Li, Tomasz Cierpicki, Jolanta Grembecka, et al. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 May 14;12(1):2792.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AS-85 2323623-80-7 AS85 AS 85 inhibitor inhibit

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