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AUTAC1

Name: AUTAC1
Brand: TargetMol
SKU: T74025
Price: 506 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74025Cas No. 2241669-09-8

AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.

AUTAC1

🥰Excellent

Purity: 99.82%

Catalog No. T74025Cas No. 2241669-09-8

AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.

Pack Size	Price	Availability	Quantity
1 mg	$506	In Stock

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Purity:99.82%

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COA HNMR HPLC LCMS

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Product Introduction

Bioactivity

Description

AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.

Chemical Properties

Molecular Weight	931.08
Formula	C₄₄H₆₃FN₈O₁₁S
Cas No.	2241669-09-8
Smiles	C[C@@]1([C@@]2([C@@]3(CO3)CC[C@@H](OC(NCCCOCCOCCOCCCNC([C@H](CSC=4N(CC5=CC=C(F)C=C5)C6=C(N4)C(=O)N=C(N)N6)NC(C)=O)=O)=O)[C@H]2OC)[H])[C@H](CC=C(C)C)O1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (85.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0740 mL	5.3701 mL	10.7402 mL	53.7011 mL
5 mM	0.2148 mL	1.0740 mL	2.1480 mL	10.7402 mL
10 mM	0.1074 mL	0.5370 mL	1.0740 mL	5.3701 mL
20 mM	0.0537 mL	0.2685 mL	0.5370 mL	2.6851 mL
50 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

AUTAC1

AUTAC1

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Dose Conversion

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