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BAY-6672 is a selective human prostaglandin F (FP) receptor antagonist that is highly potent (IC50=11 nM), orally available and well permeable. It exerts antifibrotic effects by inhibiting prostaglandin F2α (PGF₂α) activity through antagonizing the FP receptor, and has in vivo efficacy in animal models of idiopathic pulmonary fibrosis (IPF).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $196 | In Stock | |
5 mg | $498 | In Stock | |
10 mg | $725 | In Stock | |
25 mg | $1,130 | In Stock |
Description | BAY-6672 is a selective human prostaglandin F (FP) receptor antagonist that is highly potent (IC50=11 nM), orally available and well permeable. It exerts antifibrotic effects by inhibiting prostaglandin F2α (PGF₂α) activity through antagonizing the FP receptor, and has in vivo efficacy in animal models of idiopathic pulmonary fibrosis (IPF). |
In vivo | Methods: Anti-fibrotic activity of BAY-6672 (3, 10, 30 mg/kg, twice daily) in a 10-day silica-induced pulmonary fibrosis model in mice. Results: Significant reductions in relevant profibrotic and inflammatory biomarkers, including the cytokines IL-1 and MCP-1, and the ECM protein osteopontin (OPN), were observed.[1] |
Alias | BAY6672 |
Molecular Weight | 544.87 |
Formula | C26H27BrClN3O3 |
Cas No. | 2247517-53-7 |
Smiles | C(NC[C@H](CCC(O)=O)C1=C(Cl)C=CC=C1)(=O)C=2C3=C(N=C(C2C)N4CCCC4)C=CC(Br)=C3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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