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BET-IN-14
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Catalog No. T79016Cas No. 2243669-93-2
BET-IN-14 is a pan BET inhibitor with an IC50 of 5.35 nM, demonstrating oral activity and anticancer properties [1].
BET-IN-14
😃Good
Catalog No. T79016Cas No. 2243669-93-2
BET-IN-14 is a pan BET inhibitor with an IC50 of 5.35 nM, demonstrating oral activity and anticancer properties [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BET-IN-14 is a pan BET inhibitor with an IC50 of 5.35 nM, demonstrating oral activity and anticancer properties [1]. |
| In vitro | BET-IN-14 (Compound 171) exhibited antitumor activity across various cancer cell lines, with an average IC50 of 174.7 nM, particularly in MM.1S, Ty-82, MV-4-11, and KG-1 cells over 72 hours [1]. |
| In vivo | BET-IN-14 (Compound 171), administered orally at doses of 50 and 100 mg/kg once daily, inhibited tumor growth in mice with MV-4-11 xenografts [1]. |
| Molecular Weight | 527.66 |
| Formula | C30H37N7O2 |
| Cas No. | 2243669-93-2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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