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BF 227

🥰Excellent
Catalog No. T10530Cas No. 845647-80-5

BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].

BF 227

BF 227

🥰Excellent
Catalog No. T10530Cas No. 845647-80-5
BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].
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Product Introduction

Bioactivity
Description
BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].
Targets&IC50
β-Amyloid (1–42):ki： 4.3 nM
In vitro
BF-227 exhibits a high binding affinity for Aβ1-42 fibrils, with a Ki value of 4.3 nM in a competitive binding assay using [125I]BF-180 (Kd value of [125I]BF-180: 10.8 nM)[1]. The AUC for BF-227 (0.994) is significantly higher than that for FDG (0.839), indicating greater sensitivity and specificity in diagnosing AD [2].
Chemical Properties
Molecular Weight333.38
FormulaC16H16FN3O2S
Cas No.845647-80-5
Relative Density.1.336 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

BF-227BF227BF 227Aβ1-42
Related Tags: buy BF 227 | purchase BF 227 | BF 227 cost | order BF 227 | BF 227 chemical structure | BF 227 in vitro | BF 227 formula | BF 227 molecular weight
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