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BI-2852

BI-2852 is a KRAS inhibitor targeting the switch I/II pocket (SI/II-pocket) with nanomolar affinity, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

Catalog No. T10533Cas No. 2375482-51-0

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Purity:98.98%

ee:99.12%

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COA CSFC HPLC HNMR

BI-2852

Catalog No. T10533Cas No. 2375482-51-0

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Pack Size	Price	Availability
1 mg	$118	In Stock
5 mg	$291	In Stock
10 mg	$432	In Stock
25 mg	$715	In Stock
50 mg	$987	In Stock
100 mg	$1,360	In Stock
1 mL x 10 mM (in DMSO)	$330	In Stock

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Product Introduction

Bioactivity

Description	BI-2852 is a KRAS inhibitor targeting the switch I/II pocket (SI/II-pocket) with nanomolar affinity, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
Targets&IC50	KRas (G12C):450 nM, KRas (G12C):750 nM (kd)
In vitro	BI-2852 (Compound 1; 10 nM-10 μM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC50s of 6.7 μM and 5.8 μM in low serum and soft agar conditions in NCI-H358 cells.

Chemical Properties

Molecular Weight	516.59
Formula	C₃₁H₂₈N₆O₂
Cas No.	2375482-51-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (106.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9358 mL	9.6789 mL	19.3577 mL	96.7886 mL
5 mM	0.3872 mL	1.9358 mL	3.8715 mL	19.3577 mL
10 mM	0.1936 mL	0.9679 mL	1.9358 mL	9.6789 mL
20 mM	0.0968 mL	0.4839 mL	0.9679 mL	4.8394 mL
50 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9358 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.9679 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc