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BIIL-260 hydrochloride
🥰Excellent
Catalog No. T10543Cas No. 192581-24-1
Alias BIIL260 hydrochloride
BIIL-260 hydrochloride is an orally active and highly efficient leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, inhibiting LTB4-induced intracellular Ca2+ release in human neutrophils.
BIIL-260 hydrochloride
🥰Excellent
Catalog No. T10543Alias BIIL260 hydrochlorideCas No. 192581-24-1
BIIL-260 hydrochloride is an orally active and highly efficient leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, inhibiting LTB4-induced intracellular Ca2+ release in human neutrophils.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $81 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $778 | In Stock | |
| 50 mg | $1,190 | In Stock | |
| 100 mg | $1,880 | In Stock | |
| 200 mg | $2,530 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $273 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BIIL-260 hydrochloride is an orally active and highly efficient leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, inhibiting LTB4-induced intracellular Ca2+ release in human neutrophils. |
| Targets&IC50 | LTB4 receptor:1.7 nM (Ki), LTB4-induced intracellular calcium release:0.82 nM |
| In vitro | BIIL-260 hydrochloride binds to the LTB4 receptor in a reversible, competitive and saturable manner, exhibiting high affinity for the LTB4 receptor on isolated human neutrophil membranes, with a Ki value of 1.7 nM.In addition, BIIL-260 hydrochloride significantly inhibits LTB4-induced intracellular calcium release in human neutrophils, with an IC50 value of 0.82 nM. [1] |
| In vivo | In a monkey model, a single oral dose of 0.3 mg/kg of BIIL-260 hydrochloride completely inhibited LTB(4) receptor activity within 24 hours by detecting LTB(4)-induced neutropenia or Mac1 expression. [1] |
| Alias | BIIL260 hydrochloride |
| Molecular Weight | 503.03 |
| Formula | C30H31ClN2O3 |
| Cas No. | 192581-24-1 |
| Smiles | Cl.N=C(N)C1=CC=C(OCC2=CC=CC(=C2)COC3=CC=C(C=C3)C(C4=CC=C(O)C=C4)(C)C)C=C1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (198.8 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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