Biotin-β-Amyloid (1-40) is an amyloid-β-(1-40) peptide with an N-terminal biotinylation.

β-Amyloid (1-40) plays a crucial role in Alzheimer's disease as it constitutes the primary protein in brain plaques characteristic of the condition, serving as a major constituent of amyloid deposits in senile plaques. This physiological peptide is prevalent in the brain, cerebrospinal fluid (CSF), and plasma[1]. Additionally, biotin is extensively employed in the biotechnology sector to attach to proteins for biochemical analyses, facilitating qualitative and quantitative detection, labeling, or immobilization.