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Biotin-PEG6-NHS ester is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
Description | Biotin-PEG6-NHS ester is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells. |
In vitro | PROTACs, consisting of two ligands joined by a linker—one targeting an E3 ubiquitin ligase and the other the target protein—leverage the intracellular ubiquitin-proteasome system for selective protein degradation[1]. |
Molecular Weight | 676.78 |
Formula | C29H48N4O12S |
Cas No. | 2055045-04-8 |
Relative Density. | 1.31 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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