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BMT-090605

Catalog No. T14691Cas No. 1551403-51-0

BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity.

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Pack Size	Price	Availability
25 mg	$2,120	8-10 weeks
50 mg	$2,780	8-10 weeks
100 mg	$3,700	8-10 weeks

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Product Introduction

Bioactivity

Description	BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity
In vitro	BMT-090605 shows a cellular IC50 of 0.63 ±0.39 nM for AAK1[1].
In vivo	BMT-090605 (0.3-3 μg/rat; intrathecally at lumbar level L5/L6) causes antinociception by inhibiting AAK1 in the spinal cord[1]. Exposure measurements from this study indicated that brain and plasma levels of BMT-090605 were <4 nM, whereas measurable levels (90–317 nM) were observed in lumbar spinal cord[1]. The high dose of BMT-090605 (3 μg/rat) showed efficacy comparable to intrathecal clonidine (3 μg/rat).

Chemical Properties

Molecular Weight	364.44
Formula	C21H24N4O2
Cas No.	1551403-51-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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