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BMT-090605 hydrochloride

Name: BMT-090605 hydrochloride
Brand: TargetMol
SKU: T61941
Price: 35 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T61941Cas No. 2231664-45-0

BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-related kinase GAK (IC50=60 nM). BMT-090605 hydrochloride shows anti-injury activity. BMT-090605 hydrochloride has research value in neuropathic pain.

BMT-090605 hydrochloride

😃Good

Catalog No. T61941Cas No. 2231664-45-0

Pack Size	Price	Availability
25 mg	$1,810	8-10 weeks
50 mg	$2,360	8-10 weeks
100 mg	$3,610	8-10 weeks

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Product Introduction

Bioactivity

Description	BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-related kinase GAK (IC50=60 nM). BMT-090605 hydrochloride shows anti-injury activity. BMT-090605 hydrochloride has research value in neuropathic pain.
In vitro	BMT-090605 hydrochloride demonstrates significant AAK1 inhibitory activity, exhibiting an IC50 of 0.63 nM [1]. Additionally, it effectively inhibits both BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK), with IC50 values of 45 nM and 60 nM, respectively [1].
In vivo	BMT-090605 hydrochloride (intrathecal; 0.3-3 μg/rat) induces antinociception through AAK1 inhibition in the spinal cord in male Sprague-Dawley rats subjected to chronic constriction injury (CCI) [1]. A dose-dependent decrease in thermal hyperalgesia was observed, demonstrating its efficacy in reducing pain sensations.

Chemical Properties

Molecular Weight	400.91
Formula	C₂₁H₂₅ClN₄O₂
Cas No.	2231664-45-0

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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