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BrBzGCp2

Name: BrBzGCp2
Brand: TargetMol
SKU: T24598
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24598Cas No. 166038-00-2

Alias S-p-Bromobenzylglutathione cyclopentyl diester, pBrBzGSH(Cp)2, p BrBzGSH(Cp)2, BBGD, BBGC

BrBzGCp2 (p BrBzGSH(Cp)2) is an inhibitor of glyoxalase 1 (GLO1) with antitumor and neuroprotective activity. It can alleviate anxiety and be used in neurodegenerative disease research.

BrBzGCp2

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Purity: 98.68%

Catalog No. T24598Alias S-p-Bromobenzylglutathione cyclopentyl diester, pBrBzGSH(Cp)2, p BrBzGSH(Cp)2, BBGD, BBGCCas No. 166038-00-2

BrBzGCp2 (p BrBzGSH(Cp)2) is an inhibitor of glyoxalase 1 (GLO1) with antitumor and neuroprotective activity. It can alleviate anxiety and be used in neurodegenerative disease research.

Pack Size	Price	Availability	Quantity
2 mg	$48	In Stock

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Purity:98.68%

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	BrBzGCp2 (p BrBzGSH(Cp)2) is an inhibitor of glyoxalase 1 (GLO1) with antitumor and neuroprotective activity. It can alleviate anxiety and be used in neurodegenerative disease research.
Targets&IC50	Glyoxalase I:4.23 μM (GC50)
In vitro	BrBzGCp2 is an inhibitor of glyoxalase 1 (GLO1) with a GC50 of 4.23 μM in HL-60 cells. [1]
In vivo	BrBzGCp2 demonstrated an increase in dwell time in the central region of mice in open field (OF) experiments, while not significantly altering the distance traveled. GLO1 inhibition attenuated anxiety-like behavior by increasing methylglyoxal (MG) concentration. [2] Pretreatment with BrBzGCp2 shortens seizure duration. [3] BrBzGCp2 injections reduced anxiety levels in mice, and less anxiety and fear led to a greater willingness to explore unknown regions, suggesting that inhibition of GLO1 activity has a positive effect on anxiety relief. Treatment with BrBzGCp2 also restored the inhibitory effect of valproic acid (VPA) on GABAA receptor activation. [4]
Alias	S-p-Bromobenzylglutathione cyclopentyl diester, pBrBzGSH(Cp)2, p BrBzGSH(Cp)2, BBGD, BBGC

Chemical Properties

Molecular Weight	612.58
Formula	C₂₇H₃₈BrN₃O₆S
Cas No.	166038-00-2
Smiles	[C@H](CSCC1=CC=C(Br)C=C1)(C(NCC(OC2CCCC2)=O)=O)NC(CC[C@@H](C(OC3CCCC3)=O)N)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 200 mg/mL (326.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6324 mL	8.1622 mL	16.3244 mL	81.6220 mL
5 mM	0.3265 mL	1.6324 mL	3.2649 mL	16.3244 mL
10 mM	0.1632 mL	0.8162 mL	1.6324 mL	8.1622 mL
20 mM	0.0816 mL	0.4081 mL	0.8162 mL	4.0811 mL
50 mM	0.0326 mL	0.1632 mL	0.3265 mL	1.6324 mL
100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.8162 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc