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Briobacept
😃Good
Catalog No. T77906Cas No. 869881-54-9
Alias BR 3FC
Briobacept (BR 3FC), a selective human monoclonal antibody, targets BLyS (BAFF) to induce B-cell apoptosis and is a recombinant glycoprotein comprising two BLyS receptor (BR3) molecules fused to the Fc domain of human IgG1. It has applications in the study of rheumatoid arthritis (RA) [1] [2].
Briobacept
Briobacept
😃Good
Catalog No. T77906Alias BR 3FCCas No. 869881-54-9
Briobacept (BR 3FC), a selective human monoclonal antibody, targets BLyS (BAFF) to induce B-cell apoptosis and is a recombinant glycoprotein comprising two BLyS receptor (BR3) molecules fused to the Fc domain of human IgG1. It has applications in the study of rheumatoid arthritis (RA) [1] [2].
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| 5 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Briobacept (BR 3FC), a selective human monoclonal antibody, targets BLyS (BAFF) to induce B-cell apoptosis and is a recombinant glycoprotein comprising two BLyS receptor (BR3) molecules fused to the Fc domain of human IgG1. It has applications in the study of rheumatoid arthritis (RA) [1] [2]. |
| In vitro | Briobacept inhibits B cell activation and induces apoptosis by blocking circulating BLyS [3]. |
| In vivo | Briobacept, administered intraperitoneally at a dose of 100 µg/mouse for five consecutive days, suppresses basal NF-κB2 activity in wild-type mice [4]. Additionally, when given thrice weekly for a duration of five weeks, briobacept impedes p52 generation and the progression of spontaneous lupus-like disease in NZB/WF1 mice [4]. |
| Alias | BR 3FC |
| Cas No. | 869881-54-9 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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