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Bufuralol (hydrochloride)

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Bufuralol (hydrochloride)

Catalog No. T21684Cas No. 60398-91-6

Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity, which is also a CYP2D6 probe substrate [1] [2].

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Pack Size	Price	Availability
1 mg	$198	35 days
5 mg	$890	35 days
10 mg	$1,260	35 days

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Product Introduction

Bioactivity

Description	Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity, which is also a CYP2D6 probe substrate [1] [2].
In vitro	Bufuralol is widely used in the characterization of CYP2D6 activity. Bufuralol possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates [3].
In vivo	NADPH-mediated metabolism of Bufuralol exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers [4].

Chemical Properties

Molecular Weight	297.82
Formula	C16H24ClNO2
Cas No.	60398-91-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Keywords

Bufuralol (hydrochloride)Bufuralol