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Bufuralol
🥰Excellent
Catalog No. T30611Cas No. 54340-62-4
Alias Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787
Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.
Bufuralol
🥰Excellent
Purity: 98.26%
Catalog No. T30611Alias Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787Cas No. 54340-62-4
Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $455 | In Stock |
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Purity:98.26%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases. |
| In vitro | Bufuralol is a widely used substrate for assessing cytochrome P450 2D6 (CYP2D6) enzyme activity. By measuring the rate of metabolism of Bufuralol, the level of CYP2D6 activity in an individual or cell can be effectively assessed. [1] |
| In vivo | The metabolism of Bufuralol is mediated by NADPH-dependent cytochrome P450 enzymes (specifically CYP2D6) and exhibits biphasic kinetics. The metabolic efficiency of Bufuralol was significantly increased in the intestines of monkeys in the presence of hydroperoxyisopropylbenzene (CuOOH). The metabolism of Bufuralol exhibited biphasic kinetics mediated by NADPH and was more efficient in the presence of CuOOH, which was consistent with observations in the liver. [2] |
| Alias | Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787 |
| Molecular Weight | 261.36 |
| Formula | C16H23NO2 |
| Cas No. | 54340-62-4 |
| Smiles | OC(C=1OC2=C(C=CC=C2CC)C1)CNC(C)(C)C |
| Relative Density. | 1.066 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (306.09 mM.), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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