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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $78 | 35 days | |
5 mg | $353 | 35 days | |
10 mg | $595 | 35 days | |
25 mg | $1,360 | 35 days |
Description | C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease. |
Alias | C2-8 |
Molecular Weight | 510.2 |
Formula | C19H14Br2N2O3S |
Cas No. | 300670-16-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: 33 mg/mL DMSO: 33 mg/mL DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL |
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