Carbidine (Carbidin) is a derivative of gamma-carboline, an atypical antipsychotic drug. It reduces the inhibitory effect of DA on the 3H-DA release from synaptosomes of the nucleus accumbens septi and on the activity of tyrosine hydroxylase in vivo and in vitro.

After the administration of Carbidine(5 mg/kg, i.p.), the maximal IFC of Carbidine was found to be approximately 1 mu M 20-40 min after injection. Carbidine(1 mu M, i.p.) produces elevation of dopamine release not affecting sufficiently its metabolite dialysate levels. Carbidine(0.2 and 0.5 mg/kg, i.p.) stimulated locomotor activity of non-operated rats[1].